Neutral Superoxidized solution vs. benzoyl peroxide gel 5% in the treatment of acne vulgaris: a randomized open-label clinical trial. Summary. Superoxidized solution (SOS) is an electrochemically processed aqueous solution manufactured from pure water and sodium chloride. Inflammatory skin

Superoxidized solution (SOS) is an electrochemically processed aqueous solution manufactured from pure water and sodium chloride. Inflammatory skin disorders have all improved their outcomes with the use of SOS. These indications point that SOS could be useful in acne. Forty patients were enrolled in this open label, clinical trial. Patients had present with 10-50 inflammatory lesions (papules and pustules) and an abscense of nodulocystic lesions. Improvement was excellent in 7 patients (47%) using SOS compared with 5 patients (31%) using BP (p= 0.378), good in 5 patients (33%) using SOS compared with 5 patients (31%) using BP (p= 0.794), fair in 2 patients (13%), compared with 4 patients (25%) (p= 0.713) and in 1 patient (7%), the response was poor, compared with 2 patients (13%) using BP (p= 0.725). We did not require changing a dose during the study period and no systemic effect was observed. We found that SOS is an important choice to treat inflammatory acne; nevertheless, a larger sample in a double-blind, controlled clinical trial is needed.